UK – Merck’s Keytruda combination recommended by NICE for advanced gastric cancer

Merck & Co – known as MSD outside the US and Canada – has received a recommendation from the National Institute for Health and Care Excellence (NICE) for the use of Keytruda (pembrolizumab) in a subset of advanced gastric cancer patients.

The anti-PD-1 therapy has been specifically recommended for use alongside platinum- and fluoropyrimidine-based chemotherapy to treat untreated locally advanced unresectable or metastatic human epidermal growth factor 2-negative gastric or gastro-oesophageal junction adenocarcinoma in adults whose tumours express PD-L1 with a combined positive score (CPS) of one or more.

More than 6,500 new diagnoses of gastric cancer are made in the UK every year and adenocarcinomas, which develop from cells in the innermost lining of the stomach, account for the majority of cases…